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Benzothiazole compounds. XXII. Synthesis of 3- and 2,3-substituted benzothiazolium salts, investigation of their antimicrobial and growth-regulating activity

V. Sutoris, J. Halgaš, P. Foltínová, and V. Sekerka

Department of Organic Chemistry, Faculty of Natural Sciences, Komenský University, CS-842 15 Bratislava

 

Abstract:  3-Substituted and 2,3-disubstituted benzothiazolium salts were prepared by treatment of benzothiazole or 2-aIkylbenzothiazoles with reactive halides or dialkyl sulfates. The antibacterial, antifungal, and antiprotozoal activity of the salts is reported. 3-Ethyl-, 3-propyI-, and 3-butylbenzothiazolium salts were found to be active against such strains of Staphylococcus aureus which are resistant to some antibiotics. Several compounds showed good growth-stimulating and/or inhibiting activity.

Full paper in Portable Document Format: 382a247.pdf

 

Chemical Papers 38 (2) 247–253 (1984)

Monday, June 17, 2024

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