ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Identification and determination of by-products of the codeine synthesis

B. Proksa and J. Černý

Slovakofarma, CS-920 27 Hlohovec

Abstract: N,N,N',N'-Tetramethyl-4,4'-diaminodiphenylmethane, 6-methylcodeine, 17-norcodeine, α-codeimethine, and (3E)-O-dichlorovinylmorphine were found in the crude codeine obtained from morphine by methylation with trimethylphenylammonium hydroxide. A liq.-chromatog. method, employing column packed with reverse C-18-type phase, or alternatively gas-chromatog. one on XE-60/Chromaton N AW-DMCC were worked out for detn. of these products.

Full paper in Portable Document Format: 376a837.pdf

Chemical Papers 37 (6) 837–842 (1983)