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Benzothiazole compounds. XIX. Synthesis of 3-benzylbenzothiazolium salts, their growth regulation effects, and antimicrobial activities

J. Halgaš, V. Sutoris, V. Sekerka, P. Foltínová, and E. Solčániová

Department of Organic Chemistry, Faculty of Natural Sciences, Komenský University, CS-842 15 Bratislava

 

Abstract:  By treatment of substituted benzothiazole with substituted benzyl bromides the corresponding 3-benzyIbenzothiazolium salts have been prepared. The 1H-n.m.r. shifts of signals were correlated with о constants of the substituents on the benzyl part. The whole group of the synthesized compounds showed lower stimulation effect on plant growth than the used standards (IAA; 2,4-D) and mean or even low antibacterial and antifungal activities. The activity against Staphylococcus aureus was quantitatively evaluated by the Free—Wil­son analysis. The substituents on the benzyl part brought about a decrease in biological activity when compared to the unsubstituted derivatives.

Full paper in Portable Document Format: 375a663.pdf

 

Chemical Papers 37 (5) 663–676 (1983)

Monday, June 17, 2024

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