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Electrochemical determination of muscle relaxant drug tetrazepam in bulk form, pharmaceutical formulation, and human serum

Mohammed M. Ghoneim, Hanaa S. El-Desoky, Mohammed A. El-Ries, and Ashraf M. Abd-Elaziz

Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt

 

E-mail: mmghoneim@usa.net

Received: 18 May 2007  Revised: 20 July 2007  Accepted: 31 August 2007

Abstract: Tetrazepam dissolved in the Britton-Robinson universal buffer of various pH values (2.5–11.5) containing 10 vol. % of ethanol was reduced at the mercury electrode in a single 2-electron irreversible step due to reduction of the 4,5 C=N double bond of the seven-membered ring. Differential pulse polarography (DPP) and adsorptive cathodic stripping voltammetry (AdCSV) techniques (Linear sweep LS, differential pulse DP and square-wave SW modes) for quantification of tetrazepam in bulk form and in myolastan tablets are presented. Moreover, the described linear sweep, differential pulse, and square-wave adsorptive cathodic stripping voltammetry was successfully applied in quantification of tetrazepam in spiked human serum without any prior extraction of the drug. The obtained results showed an increased sensitivity of the described electro-analytical procedures for the quantification of tetrazepam in the following order DPP, DP-AdCSV, LS-AdCSV, and SW-AdCSV, since the observed limits of tetrazepam quantitation by these electroanalytical techniques were 5 × 10−6 mol L−1, 3 × 10−7 mol L−1, 1 × 10−8 mol L−1, and 3 × 10−9 mol L−1, respectively.

Keywords: tetrazepam - myolastan tablets - human serum - polarography - stripping voltammetry

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-008-0001-7

 

Chemical Papers 62 (2) 127–134 (2008)

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