ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Synthesis of new quinoxalinophenazinediones and tetrahydrobenzodipyrrolotetrones of biological interest
Ahmed S. Hammam, Mohamed S. K. Youssef, Ferial M. Atta, and Thana A. Mohamed
Department of Chemistry, Faculty of Science, Assiut University, 71516 Assiut, Egypt
Received: 10 March 2007 Revised: 1 July 2007 Accepted: 19 July 2007
Abstract: The reaction of two equivalents of sodium azide with diarylaminodibromo-p-benzoquinone (I) in DMF for 15–24 h produced quinoxalinophenazinediones together with a byproduct identified as diarylaminodiaminobenzoquinone.
On the other hand, the reaction of bromanil with active methylenes, such as diethyl malonate and ethyl acetoacetate, resulted
in disubstitution products which, on treatment with primary amines, cyclized into benzodipyrroletetrones. Comparative antifungal
and antibacterial studies were made.
Keywords: quinoxalinophenazinediones - tetrahydrobenzodipyrrolotetrones - synthesis - antimicrobial activity - antifungal activity - acute toxicity
Full paper is available at www.springerlink.com.
Chemical Papers 62 (2) 194–206 (2008)
Thursday, August 18, 2022