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Synthesis and antimicrobial activity of 2-(alkylthio)-6-(bicyclo[2.2.1]hept-5-ene-2,3-dicarboximidomethylamino)benzothiazoles

E. Sidóová, Ž. Odlerová, and G. Blőckinger

Institute of Chemistry, Komenský University, 816 50 Bratislava

 

Abstract: The title compds. I (R = alkyl) were prepd. by Mannich reaction of bicyclo[2.2.1]hept-5-en-2,3-dicarboximide and 2-alkylthio-6-aminobenzothiazoles and tested for antimycobacterial activity against tuberculosis mycobacteria and for antiviral activity. The antimycobacterial activity of the synthesized compds. was evidently lower than that of the starting 2-alkylthio-6-aminobenzothiazoles and 2-alkylthio-6-(bicyclo[2.2.1]hept-5-en-2,3-dicarboximido)benzothiazoles.

Full paper in Portable Document Format: 334a542.pdf

 

Chemical Papers 33 (4) 542–546 (1979)

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