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Benzothiazole compounds. VIII. Synthesis and microbiological activity of N-substituted 6-amino-2-methylthiobenzothiazoles

V. Sutoris, Ľ. Orosová, and P. Foltínová

Department of Organic Chemistry, Faculty of Natural Sciences, Komenský University, 801 00 Bratislava

 

Abstract: 6-Alkylamino-, 6-dialkyIamino-, 6-arylamino-, 6-diarylamino-, 6-(N-alkyl-N-nitrosoamino)-, and 6-(N-aryl-N-nitrosoamino)-2-methylthiobenzothiazoles, not de­scribed up to now, were synthesized and their antibacterial activities were studied. Their structures were proved by evaluation of the i.r. and p.m.r. spectra. The highest antibacterial activity was found with 6-methylamino-2-methylthiobenzothiazole (/), 6-(p-nitrophenylamino)-2-methylthiobenzothiazole (XIV), 6-(di-p-nitrophenylamino)-2-methylthiobenzothiazole (XV), and 6-(2,4-dinitrophenylamino)-2-methylthiobenzothiazole (XVII). The minimum inhibition concentration for Bacillus subtilis and Escherichia coli was 50  μg/mL.

Full paper in Portable Document Format: 302a179.pdf

 

Chemical Papers 30 (2) 179–185 (1976)

Monday, June 17, 2024

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