ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Chelating agents derived from cysteine. Synthesis, dissociation constants and complexes with silver(I)

M. Struhár, L. Sirotková, and E. Dvořáková

Pharm. Fac., Komensky Univ., Bratislava

Abstract:  Compounds of the type of alkanedithio-bis(2-aminopropane) acids were prepared by the reaction of dihalogenoalkane (namely dibromomethane, 1,2-dibromoethane, 1,3-dibromopropane, 1,4-dibromobutane, and 1,3-dichloro-2-propanol) with L-cysteine. Values of рK_а were determined and the complex formation with Ag(I) was followed from the potentiometrical neutralization curves (I = 0.10 M, KNO₃, 20°C). Complexes with the ratio M : L = 1 1 and hydrogeno complexes are formed. The effect of lengthening of the carbon chain as well as the presence of covalently bonded sulfur was followed.

Full paper in Portable Document Format: 296a740.pdf (in German)

Chemical Papers 29 (6) 740–744 (1975)