ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Influence of p-Aminobenzoic Acid, p-Hydroxybenzoic Acid and L-Tryptophan on Biosynthesis of Chloramphenicol

B. Škárka, D. W. S. Westlake, and L. C. Vining

Department of Microbiology and Biochemistry, Slovak Technical University, Bratislava 1

Abstract: Westlake et al. found or verified the part of the biosynthetic pathway of chloramphenicol to shikimic acid and from L-p-aminophenylalanine to chloramphenicol. The part between shikimic acid and L-p-aminophenylalanine is still unknown. The influence of some aromatic compounds on the production of chloramphenicol was studied using the derivatives of chorismic acid (tryptophan, p-aminobenzoic acid and p-hydroxybenzoic acid) and prephenic acid (tyrosine and phenylalanine). The derivatives of chorismic acid stimulated the production of chloramphenicol while the derivatives of prephenic acid did not. The biosynthetic pathway of chloramphenicol from shikimic acid appears to be very close to the pathways for tryptophan, p-aminobenzoic and p-hydroxybenzoic acids or common to an unknown branch point

Full paper in Portable Document Format: 241a66.pdf

Chemical Papers 24 (1) 66–72 (1970)