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Thioxo analogs of 6-azauracil. IV. Distribution of 2-thio-6-azathymine in rats

F. Horák and O. Thomesová

Department of Organic Technology, Slovak Technical University, Bratislava


Abstract: After the peroral administration of 2-thio-6-azathymine this substance is absorbed in the digestive tract and according the experiment on the isolated rat intestine already here it is partially metabolised. Using 2-thio-6-azathymine-35S, and compound labelled by radiactive carbon, seven and eight metabolites, respectively were found. Six of the mentioned substances have the common centers from the position 2 and 4 of the original molecule. Furthermore, it was proved, that during 24 hours ca 70 % of the applicated substance was excreted by urine. Approximately 1/7 from the given dosis of 2-thio-6-azathymine was excreted unchanged. Besides this 6-azathymine, 2-methylmercapto-6-azauracil and sulphate anion were proved to be present in urine. In expired air, carbon dioxane was proved. The remaining four metabolites have not been so far identified. Three of them afford the possitive nitroprusside reaction. In. the presented work the uptake of the radioactive substance by thyroid was investigated. It was found that its amount was increased in time and in 24 hours it makes 0,43%.

Full paper in Portable Document Format: 201a69.pdf (in Slovak)


Chemical Papers 20 (1) 69–78 (1966)

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