ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7

Published monthly
 

The reduction of 1-benzyloxymethyl-3,4-dihydro-6,7-dimethoxyisoquinoline

I. Ježo, M. Karvaš, and K. Tihlárik

Slovak Academy of Sciences, Bratislava

 

Abstract: It was established that by the redn. of 1-benzyloxymethyl-3,4- dihydro-6,7-dimethoxyisoquinoline with Zn in HCl or with metal Na in abs. EtOH, D,L-Salsolidine (I) was formed in place of the expected 1-benzyloxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (II). I b. 125°/0.2 mm., the base m. 52-3°, the HCl salt m. 194° (EtOH); picrate m. 201° (EtOH), picrolonate m. 238-9° (EtOH) 0.5 H2PtCl6 salt m. 208° (EtOH). With Sn in HCl, the expected II was formed; HCl salt m. 212-13° (EtOH); picrate m. 211-12° (EtOH); methiodide m. 208-9° (EtOH); 0.5 H2PtCl6 salt m. 212-13° (EtOH); picrolonate m. 193-4° (EtOH). The action of Al amalgam in damp Et2O did not result in the redn. of the double bond and the original II could be isolated from the reaction medium.

Full paper in Portable Document Format: 141a38.pdf (in Slovak)

 

Chemical Papers 14 (1) 38–43 (1960)

Monday, December 02, 2024

IMPACT FACTOR 2023
2.1
SCImago Journal Rank 2023
0.381
SEARCH
Advanced
VOLUMES
© 2024 Chemical Papers