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In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes

Ajay K. Mishra, Shivani B. Mishra, and Narender K. Kaushik

Department of Chemical Technology, University of Johannesburg, Doornfontein, 2028, South Africa



Received: 9 October 2008  Revised: 1 December 2008  Accepted: 4 December 2008

Abstract: Synthesis, characterization and biological studies of some thiodiamine metal complexes are described. Cobalt(II) and copper(II) complexes of type [Cu(L)2Cl2] and [Co(L)2SO4], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L1) and (cyclohexyl-N-thio)-1,3-propanediamine (L2), were synthesized. The synthesized copper and cobalt thiodiamine complexes were characterized by elemental analysis, IR, mass, UV-VIS and 1H NMR spectroscopic studies. Thiodiamines coordinate as a bidentate N-S ligand. The binding sites are azomethine nitrogen and thioamide sulfur. Molar conductance values in dimethylsulfoxide indicate non-electrolyte nature of the complexes. In vitro-antimicrobial screening shows promising results against both bacterial and fungal strains.

Keywords: synthesis - thiodiamine - spectral - antibacterial - antifungal

Full paper is available at

DOI: 10.2478/s11696-009-0049-z


Chemical Papers 63 (5) 543–547 (2009)

Monday, April 19, 2021

SCImago Journal Rank 2019
XXVIII. International Conference on Coordination and Bioinorganic Chemistry
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