ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes
Ajay K. Mishra, Shivani B. Mishra, and Narender K. Kaushik
Department of Chemical Technology, University of Johannesburg, Doornfontein, 2028, South Africa
Received: 9 October 2008 Revised: 1 December 2008 Accepted: 4 December 2008
Abstract: Synthesis, characterization and biological studies of some thiodiamine metal complexes are described. Cobalt(II) and copper(II)
complexes of type [Cu(L)2Cl2] and [Co(L)2SO4], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L1) and (cyclohexyl-N-thio)-1,3-propanediamine (L2), were synthesized. The synthesized copper and cobalt thiodiamine complexes were characterized by elemental analysis, IR,
mass, UV-VIS and 1H NMR spectroscopic studies. Thiodiamines coordinate as a bidentate N-S ligand. The binding sites are azomethine nitrogen
and thioamide sulfur. Molar conductance values in dimethylsulfoxide indicate non-electrolyte nature of the complexes. In vitro-antimicrobial
screening shows promising results against both bacterial and fungal strains.
Keywords: synthesis - thiodiamine - spectral - antibacterial - antifungal
Full paper is available at www.springerlink.com.
Chemical Papers 63 (5) 543–547 (2009)