ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Polarographic determination of warfarin
Forschungsinstitut für agrochemische Technologie in Bratislava
Abstract: An indirect polarographic method is based on the formation of CHI3 in alk. medium with the acetyl radical: CH3COR + 6I + 3NaOH = CI3COR + 3NaI + 3H2O; CI3COR + NaOH = CHI3 + RCOONa. Pptd. CHI3 is filtered off, dissolved in MeOH, and detd. polarographically. Because CHI3 reaction is not quant., exptl. factor, detd. polarographically, is used for calcn. of warfarin.
Full paper in Portable Document Format: 86a342.pdf (in Slovak)
Chemical Papers 8 (6) 342–345 (1954)