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Hypnotically active triazenes

I. Ježo, F. Selecký, and J. Tamchyna

Research Institute of Pharmaceutical, Bratislava

 

Abstract: New derivs. of substituted barbituric, acids were prepd. The basis of these compds. is the double lactam, MeN(N.CO.NH.CO.CR1R2CO)2 (I). The I are prepd. from the suitably substituted barbituric acid with MeNCl2 in CHCl3 solution at elevated temp. The Na salts of the allylisopropyl (II) (I, R1 = allyl, R2 = iso-Pr) and butylethyl (III) compds. were tested for their narcotic activities and compared with the Na salt of 5-(2-bromoallyl)-5-isopropyl-1-methylbarbituric acid (IV). II and III acted almost as rapidly as IV but caused a longer narcotic state (5-6 hrs., depending on the dosage) and exhibited lower toxicity than IV. The I are very labile compds. and decomp. within 100 days.

Full paper in Portable Document Format: 53-4a121.pdf (in Slovak)

 

Chemical Papers 5 (3-4) 121–132 (1951)

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