ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Three-component one-pot reaction for the synthesis of β-amide ketones

Yan-Ping Luo and Qiong Chen

Key Laboratory of Protection and Development Utilisation of Tropical Crop Germplasm Resources, Hainan University, Ministry of Education, HaiKou, 570228, China

E-mail: yanpluo@yahoo.com.cn

Abstract: β-amide ketones were synthesised by a three-component one-pot reaction of phenylacetylene, aldehydes, and amides in anhydrous acetonitrile containing trifluoroacetic acid and acetic acid in the presence of AlCl₃ catalyst. The title compound structures were identified by ¹H NMR, ¹³C NMR, MS, and elemental analysis.

Keywords: β-amide ketones – one-pot reaction – synthesis

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-013-0313-0

Chemical Papers 67 (5) 532–537 (2013)