ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Preparation, spectral, thermal, and biological properties of zinc(II) 4-chloro- and 5-chlorosalicylate complexes with methyl 3-pyridylcarbamate and phenazone

Zuzana Bujdošová, Katarína Györyová, Daniela Hudecová, Jana Kovářová, and Ladislav Halás

Department of Inorganic Chemistry, P. J. Šafárik University, Moyzesova 11, 041 54 Košice, Slovakia

E-mail: zuzana.bujdosova@upjs.sk

Abstract: New zinc(II) 4-chloro- and 5-chlorosalicylate complex compounds of the general formula ((4- or 5-Cl)C₆H₃(2-OH)COO)₂Zn · L _n (where L = methyl 3-pyridylcarbamate, phenazone; n = 2, 4) were prepared and characterized by elemental analysis, thermal analysis (TG/DTG, DTA), and IR spectroscopy. During thermal decomposition, mpc, phen, chlorosalicylic acid, chlorophenol, carbon dioxide, and carbon monoxide were released. Volatile products of the thermal decomposition were confirmed by mass spectrometry. The final solid product of the thermal decomposition up to 700°C was zinc oxide or metallic zinc. Antimicrobial activity of the compounds prepared was tested against various strains of bacteria, yeasts and filamentous fungi. The highest antimicrobial effect was determined against the G⁺ bacteria S. aureus.

Keywords: methyl 3-pyridylcarbamate - phenazone - zinc(II) chlorosalicylate - thermal and biological properties - IR spectra

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-010-0039-1

Chemical Papers 64 (5) 584–591 (2010)