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Asymmetric synthesis of machilin C and its analogue

Yamu Xia and Wei Wang

College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042 China

 

E-mail: xiaym@qust.edu.cn

Abstract: Full details of the asymmetric total synthesis of erythro-8-O-4′-neolignan, machilin C, and its analogue perseal A are reported. The synthesis was involved in the Sharpless dihydroxylation reaction that occurred with excellent asymmetric induction, and the Mitsunobu reaction which occurred with inversion of the absolute configuration from the threo to the erythro isomer. The synthesis was achieved from simple vanillin in eight to twelve steps.

Keywords: neolignans - machilin C - perseal A - asymmetric synthesis

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-010-0040-8

 

Chemical Papers 64 (5) 630–636 (2010)

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