ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus
Ilona Bakai-Bereczki, Mihály Herczeg, Bernadett György, Lieve Naesens, and Pál Herczegh
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Egyetem tér 1., 4032 Debrecen, Hungary
Abstract: In order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin.
Keywords: ristocetin aglycone – influenza virus – antiviral activity – sialoconjugate
Full paper is available at www.springerlink.com.
Chemical Papers 69 (8) 1136–1140 (2015)
Thursday, September 29, 2022