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Multi-component synthesis of highly substituted imidazoles catalyzed by nanorod vanadatesulfuric acid

Masoud Nasr-Esfahani, Morteza Montazerozohori, and Tooba Abdizadeh

Department of Chemistry, Yasouj University, Yasouj 75918-74831, Iran



Abstract: Nanorod vanadatesulfuric acid (VSA NRs), as a recyclable and eco-benign catalyst, was used for one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles using aldehydes, benzil, benzoin or 9,10-phenanthrenequinone and ammonium acetate or aniline under solvent-free conditions providing high to excellent yields. VSA is easily prepared by a simple reaction of chlorosulfonic acid and sodium metavanadate in high purity. As compared with the conventional procedures, the present protocol offers several advantages such as simplicity of procedure, short reaction time, high yields, easy workup, recoverability and reusability of the catalyst and simple purification of the products.

Keywords: vanadatesulfuric acid – 2,4,5-trisubstituted imidazoles – 1,2,4,5-tetrasubstituted imidazoles – reusable catalyst – heterogeneous catalyst – nanorod particles

Full paper is available at

DOI: 10.1515/chempap-2015-0156


Chemical Papers 69 (11) 1491–1499 (2015)

Wednesday, June 19, 2024

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