ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
SOD mimetic activity of salicylatocopper complexes
Miroslava Puchoňová, Jozef Švorec, Ľubomír Švorc, and Dušan Valigura
Institute of Inorganic Chemistry, Slovak University of Technology in Bratislava, Radlinskeho 9, 812 37 Bratislava, Slovakia
Abstract: Investigation of salicylatocopper complexes in the presence of a nitrogen donor ligand is a growing research area due to the interesting mimetic activities of such complexes. Here, three X-salicylatocopper (where X = 3-methyl, or 4-methoxy) complexes with three different N-donor ligands, [Cu(μ-menia)(3-Mesal)2(menia)(H2O)]2 (I ), Cu(3-Mesal)2(denia)2(H2O)2 (II ), Cu(4-MeOsal)2(2-pyme)2 (III ), are presented (where 3-Mesal = 3-methysalicylate, 4-MeOsal = 4-methoxysalicylate, menia = N-methylnicotinamide, 2-pyme = 2-pyridylmethanol). The complexes were characterized by elemental analysis, IR and UV-VIS spectrophotometry. Cyclic voltammetry and the superoxide dismutase activity of the prepared complexes in solution were measured and the complexes were characterized by means of the inhibition concentration IC50. In addition, the superoxide dismutase (SOD) activity of these complexes was compared with those of the parent ligand copper acetate, native SOD enzyme, and the related copper complexes containing non-steroidal anti-inflammatory drugs. The resulting SOD activity was correlated to the composition, structure and redox stability of the prepared complexes. The best value of the inhibition concentration was found for complex I (IC50 = 2.24 μM), which classifies this complex into a group of good superoxide scavengers.
Keywords: methyl- and methoxysalicylate – superoxide dismutase activity – spectroscopic properties – cyclic voltammetry
Full paper is available at www.springerlink.com.
Chemical Papers 70 (1) 75–81 (2016)