ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
Registr. No.: MK SR 9/7
Synthesis and antimicrobial properties of new 2-((4-ethylphenoxy)methyl)benzoylthioureas
Carmen Limban, Alexandru V. Missir, Ileana C. Chirita, George M. Nitulescu, Miron T. Caproiu, and et al.
Pharmaceutical Chemistry Department, Faculty of Pharmacy, “Carol Davila”, University of Medicine and Pharmacy, Traian Vuia 6, Bucharest, 020956 Romania
Abstract: New acylthiourea derivatives, 2-((4-ethylphenoxy)methyl)-N-(phenylcarbamothioyl)benzamides, were tested by qualitative and quantitative methods on various bacterial and fungal strains
and proved to be active at low concentrations against Gram-positive and Gram-negative bacteria as well as fungi. These compounds
were prepared by the reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate with various primary aromatic amines, and
were characterised by melting point and solubility. The structures were identified by elemental analysis, 1H and 13C NMR, and IR spectral data. The level of antimicrobial activity of the new 2-((4-ethylphenoxy)methyl)benzoylthiourea derivatives
was dependent on the type, number and position of the substituent on the phenyl group attached to thiourea nitrogen. The iodine
and nitro substituents favoured the antimicrobial activity against the Gram-negative bacterial strains, while the highest
inhibitory effect against Gram-positive and fungal strains was exhibited by compounds with electron-donating substituents
such as the methyl and ethyl groups.
Keywords: acylthiourea – 2-((4-ethylphenoxy)methyl)benzoic acid – 1H NMR – 13C NMR – antimicrobial activity
Full paper is available at www.springerlink.com.
Chemical Papers 65 (1) 60–69 (2011)
Tuesday, January 31, 2023