ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis and antibacterial evaluation of novel Schiff base derivatives containing 4(3H)-quinazolinone moiety

Mei-Hang Chen, Xiao-Bing Wang, Bang-Cheng Tang, and Xun Zhang

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China

E-mail: chenmeihang0123@126.com

Abstract: A series of novel Schiff base derivatives containing 4(3H)-quinazolinone moiety were synthesised and their antibacterial activities against tobacco and tomato bacterial wilts evaluated in vitro. Out of the synthesised compounds, 5g, 5j, 5n, 5m and 5p exhibited excellent antibacterial activities against tobacco bacterial wilt, with half maximal effective concentrations (EC₅₀): 160.34, 158.03, 125.94, 148.09 and 133.67 (all in μg mL⁻¹), respectively, which were better than the EC₅₀ of thiodiazole–copper (216.70 μg mL⁻¹). Compounds 5j, 5n and 5o also showed good antibacterial activities against tomato bacterial wilt, with EC₅₀ of 95.20, 90.03 and 83.21 (all in μg mL⁻¹) respectively, which were better than the EC₅₀of thiodiazole–copper (99.80 μg mL⁻¹). These compounds may prove to be useful as potential antibacterial agents.

Keywords: Schiff base derivatives – 4(3H)-quinazolinone – synthesis – antibacterial activity

Full paper is available at www.springerlink.com.

DOI: 10.1515/chempap-2016-0090

Chemical Papers 70 (11) 1521–1528 (2016)