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Microwave-assisted synthesis of 1,4-bis(difluoromethyl)benzene

Dong-Hui Pan, Tong-Zhen Wang, and Guo-Min Xiao

School of Chemistry and Chemical Engineering, Southeast University, Nanjing, People’s Republic of China

 

E-mail: xiaogm426@gmail.com

Abstract: A fast, mild, and practical microwave-assisted protocol for synthesis of 1,4-bis(difluoromethyl)benzene from 1,4-bis(dichloromethyl)benzene and KF was developed. The new protocol increased the yield and reduced the reaction time significantly in contrast to the conventional heating procedure. Also, the synergistic effect of a composite phase transfer catalyst was studied.

Keywords: Microwave-assisted synthesis, 1,4-bis(difluoromethyl)benzene, Phase transfer catalyst fluorination

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-016-0118-z

 

Chemical Papers 71 (7) 1249–1254 (2017)

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