ISSN print edition: 0366-6352
ISSN electronic edition: 1336-9075
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Ultrasensitive bioelectronic devices based on conducting polymers for electrophysiology studies

Sanaz Asgarifar, Pedro M. C. Inácio, Ana L. G. Mestre, and Henrique Leonel Gomes

Universidade do Algarve, Faro, Portugal



Abstract: Conducting polymer electrodes based on poly(3,4-ethylenedioxythiophene doped with poly(styrenesulfonate) (PEDOT:PSS) are evaluated as transducers to record extracellular signals in cell populations. The performance of the polymer electrode is compared with a gold electrode. A small-signal impedance analysis shows that in the presence of an electrolyte, the polymer electrode establishes for frequencies below 100 Hz a higher capacitive electrical double layer at the electrode/electrolyte interface. Furthermore, the polymer/electrolyte interfacial resistance is several orders of magnitude lower than the resistance of the gold/electrolyte interface. The polymer low interfacial resistance minimizes the intrinsic thermal noise and increases the system sensitivity. The ultra-sensitivity of the polymer-based transducer system was demonstrated by recording the electrical activity of cancer cells of the nervous system.

Keywords: Organic bioelectronics ; Polymer electrodes ; Extracellular signals ; PEDOT:PSS 

Full paper is available at

DOI: 10.1007/s11696-018-0481-z


Chemical Papers 72 (7) 1597–1603 (2018)

Monday, June 17, 2024

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