ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Tailored doxycycline delivery from MCM-41-type silica carriers

Mihaela Deaconu, Ioana Nicu, Robert Tincu, Ana-Maria Brezoiu, Raul-Augustin Mitran, Eugeniu Vasile, Cristian Matei, and Daniela Berger

University “Politehnica” of Bucharest, Bucharest, Romania

E-mail: danaberger01@yahoo.com

Abstract: Doxycycline, an antibiotic from the tetracycline class with a broad spectrum of activity, was used to prepare drug delivery systems based on pristine and functionalized mesostructured silica supports. MCM-41-type materials with different textural, structural, and surface properties were used to assess their influence on the drug release kinetics. Small- and wide-angle XRD, FTIR spectroscopy and N₂ adsorption/desorption isotherms were used to characterize the carriers before and after doxycycline loading. The drug release experiments were performed in vitro in 0.2 M phosphate buffer solution at 37 °C, and the slowest drug release kinetics was obtained for magnesium-modified MCM-41 carrier. All drug-loaded materials exhibited good antibacterial activity against Klebsiella pneumoniae ATCC 10031 strain, similar to the drug alone.

Keywords: Drug delivery systems ; Doxycycline ; Mesoporous silica ; Release kinetics ; Functionalized silica 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-018-0457-z

Chemical Papers 72 (8) 1869–1880 (2018)