ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis, antibacterial, and antiviral activities of novel penta-1,4-dien-3-one derivatives containing a benzotriazin-4(3H)-one moiety

Ju-Ping Zhang, Qin Li, Cheng Zhang, Pu Li, Li-Juan Chen, Yi-Hui Wang, Xiang-Hui Ruan, Wei Xiao, and Wei Xue

Guizhou University, Guiyang, China

E-mail: wxue@gzu.edu.cn

Abstract: A series of penta-1,4-dien-3-one containing a benzotriazin-4(3H)-one moiety were prepared and evaluated for their antibacterial and antiviral activities. Bioassays indicated that some compounds exhibited good antibacterial and antiviral activities. Among them, the EC₅₀ values of compound 6d against Xanthomonas axonopodis pv. citri and compound 6l against Ralstonia solanacearum were, respectively, 22.45 and 34.77 μg/mL, which were better than that of thiodiazole copper (51.35 and 87.26 μg/mL, respectively). Meanwhile, some title compounds were found to show remarkable antiviral activities against tobacco mosaic virus (TMV). These results indicated that penta-1,4-dien-3-one derivatives containing benzotriazin-4(3H)-one moiety could play significant roles in searching for novel agrochemicals.

Keywords: Penta-1,4-dien-3-one ; Antiviral ; Antibacterial ; Benzotriazin-4(3H)-one 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-018-0422-x

Chemical Papers 72 (9) 2193–2202 (2018)