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Enantioseparation of novel psychoactive chiral amines and their mixture by capillary electrophoresis using cyclodextrins as chiral selectors

Klára Řezanková, Radka Kohoutová, Martin Kuchař, Vladimír Král, and Pavel Řezanka

University of Chemistry and Technology, Prague, Czech Republic



Abstract: The prevalence of new psychoactive substances (NPS) has been increasing during the last decade as well as their constant growth of availability across the whole world. Regardless of the potential health hazard, NPS (often racemic compounds) are frequently sought after and abused for their psychoactive effects that may differ for individual enantiomers. In this work, capillary electrophoresis was used for the chiral separation of a mixture of eleven psychoactive chiral amines using β-cyclodextrin and carboxymethyl-β-cyclodextrin as chiral selectors at various concentrations. Chiral separation was successful for all the analytes studied. A mixture of these analytes was subsequently analyzed under optimal conditions, i.e., when using 20 mmol/L carboxymethyl-β-cyclodextrin in 50 mmol/L sodium phosphate buffer, pH 2.5. In this case, chiral separation occurred in nine out of eleven analytes. To our best knowledge, we achieved enantioseparations of seven analyzed compounds by CE for the first time.

Keywords: Capillary electrophoresis ; Chiral separation ; Enantioselectivity ; Psychoactive substances 

Full paper is available at

DOI: 10.1007/s11696-018-0535-2


Chemical Papers 72 (11) 2737–2743 (2018)

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