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FeCl2·4H2O catalyzed ritter reaction with nitriles and halohydrocarbons

Cheng-Liang Feng, Gui-Bo Yin, Bin Yan, Jun-Qing Chen, and Min Ji

Jiangsu College of Engineering and Technology, Nantong, People’s Republic of China

 

E-mail: fcl085620@163.com

Abstract: An efficient and inexpensive synthesis of N-substituted amides from the Ritter reaction of nitriles with various halohydrocarbons catalyzed by FeCl2·4H2O is described. FeCl2·4H2O economically efficiently catalyzed the Ritter reaction under solvent-free conditions. A range of halohydrocarbons (benzyl, tert-butyl and sec-alkyl halohydrocarbons) were coupled with nitriles to provide the corresponding amides in high to excellent yields.

Keywords: FeCl2·4H2O ; Amides ; Nitriles ; Halohydrocarbons ; Ritter reaction 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-018-0585-5

 

Chemical Papers 73 (2) 345–353 (2019)

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