ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Practical synthesis of silyl-protected and functionalized propargylamines using nanostructured Ag/TiO₂ and Pt/TiO₂ as active recyclable catalysts

Yasser M. A. Mohamed, Hossam A. El Nazer, and Eirik Johansson Solum

National Research Center, Giza, Egypt

E-mail: y.m.a.mohamed@outlook.com

Abstract: Herein we report the use of Ag/TiO₂ and Pt/TiO₂ nanocatalysts to promote the synthesis of a series of silyl-protected and functionalized propargylamine derivatives through alkyne–amine–aldehyde (A³) coupling under microwave condition using water as solvent in short reaction times with high yielding production. A comparative study between the two catalysts was also demonstrated to prove that Pt/TiO₂ nanocomposite has higher potential effect for propargylamines synthesis more than Ag/TiO₂. The main features of the investigated method for propargylamines synthesis were easy handling, low catalyst loading as well as the feasibility of catalyst recyclability. The prepared compounds are potentially beneficial with possible pharmacological and biological properties, which that could be used in several disciplines including medicinal and agricultural applications.

Keywords: Metal-doped TiO₂ ; Nanocatalysis ; Propargylamine ; Multicomponent reaction ; Recyclability 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-018-0604-6

Chemical Papers 73 (2) 435–445 (2019)