ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Silica-supported ceric ammonium nitrate (CAN): a simple, mild and solid-supported reagent for quickest oxidative aromatization of Hantzsch 1,4-dihydropyridines

Parvin Kumar, Kulbir Kadyan, Meenakshi Duhan, Jayant Sindhu, Khalid Hussain, and Sohan Lal

Kurukshetra University, Kurukshetra, India

E-mail: parvinchem@kuk.ac.in

Abstract: An efficient and environmentally benign methodology for the oxidative aromatization of 1,4-dihydropyridines to their corresponding pyridine derivatives is developed. The oxidative aromatization of 1,4-dihydropyridines was explored using silica-supported ceric ammonium nitrate as catalyst in CH₃CN with or without sonication at room temperature. This supported catalyst acts as a more efficient oxidising reagent and offers several advantages over other reported reagents in terms of reaction time and yields. The supported reagent is found to be more efficient and selective when compared with its unsupported form. The Belousov–Zhabotinskii reaction was not observed in present reaction. The dealkylation observed in case of 4-n-alkyl/n-alkenyl with other oxidising agents is also not observed in the present case.

Keywords: Silica supported ; CAN ; 1,4-DHP ; Ultrasonication ; Oxidation 

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-018-0666-5

Chemical Papers 73 (5) 1153–1162 (2019)