ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Zirconium(IV) 4-sulphophenylethyliminobismethylphosphonate as an efficient and reusable catalyst for one-pot synthesis of 3,4-dihydropyrimidones under solvent-free conditions

Xin-Bin Yang, Xiang-Kai Fu, Yu Huang, and Ren-Quan Zeng

Department of Chemistry, Rongchang Campus, Southwest University, Chongqing, 402460 China

E-mail: yangxbqq@126.com

Abstract: Zirconium(IV) 4-sulphophenylethyliminobismethylphosphonate (ZSBEDP) was prepared and characterised by elemental analysis, IR, TG-DSC, and XRD. ZSBEDP was found to be an efficient catalyst for the Biginelli reaction of aromatic aldehyde, ethyl acetoacetate, and urea or thiourea under solvent-free conditions so as to give 3,4-dihydropyrimidones in good to excellent yields. The catalyst can be separated by simple filtration and reused without significant loss of its catalytic activity.

Keywords: zirconium – phosphonate – acid catalyst – 3,4-dihydropyrimidones – solvent-free

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-011-0091-5

Chemical Papers 65 (6) 829–834 (2011)