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Express analysis of amoxicillin via colorimetric testing

Anastasia V. Marakaeva and Irina V. Kosyreva

Chemistry Institute, Saratov State University, Saratov, Russia

 

E-mail: marakaeva_anastasiya@mail.ru

Received: 25 September 2019  Accepted: 29 January 2020

Abstract:

Falsified drugs are a serious problem of modern society. Therefore, it is necessary to develop a fast and simple method of drug screening for checking of their falsification. In this article, we present paper-based test methods that can be used to identify amoxicillin, a β-lactam series antibiotic agent, used the mobile phone camera. The detection time is 10 min. Ninhydrin, p-dimethylaminobenzaldehyde, and Fehling’s reagent are used as reagents for the test. We have found out the optimal conditions of express analysis, including temperature and duration of heating. We have obtained the color scales for visual and colorimetric detection of the antibiotic agent. Optimal color parameters for RGB, CMYK, and HSV color models have been analyzed. We have demonstrated linear correlations between optimal colorimetric parameters and antibiotic agent concentration. Profiles of radar diagrams using color parameters as coordinates are obtained. Linear correlation between area and perimeter of radar diagrams and amoxicillin concentration was found.

Keywords: Express analysis; Indicator papers; Antibiotic agents; Amoxicillin; Phone camera-based detection; Colorimetry

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-020-01085-6

 

Chemical Papers 74 (8) 2381–2388 (2020)

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