ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Identification of chiral lansoprazole drugs using THz fingerprint spectroscopy

Hua Chen, Juan Han, Jie Liu, Lei Gao, and Shihua Ma

School of Physics, Southeast University, Nanjing, China

E-mail: chenhua@seu.edu.cn

Received: 5 June 2022  Accepted: 3 October 2022

Abstract:

Lansoprazole, as a typical peptic ulcer disease (PUD) chiral drug, was investigated using terahertz (THz) fingerprint spectroscopy. Lansoprazole, S-lansoprazole, and R-lansoprazole had characteristic absorption peaks at 1.50 THz, 1.78 THz, and 2.00 THz, respectively, which can be used as the basis to qualitatively identify chiral lansoprazole drugs. In this study, a density functional theory (DFT) simulation was performed to gain insight into the origin of the characteristic absorption peak. The DFT calculation results were consistent with our experimental THz spectroscopic data and indicated that the characteristic absorption peaks came from the different vibrational modes induced by different polymorphs of the lansoprazole samples.

Keywords: THz; Fingerprint; Lansoprazole; Absorption coefficients; DFT

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-022-02529-x

Chemical Papers 77 (2) 887–893 (2023)