ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Supramolecular structural-based fabrication of silver nanoparticles using diamide derivative of calix[4]arene: an efficient antimicrobial agent

Anwar Ali Chandio, Shahabuddin Memon, Aijaz Otho, Awais Khalid, Bader S. Alotaibi, Amna Balouch, Nazir Ahmed Brohi, Fakhar N. Memon, Ayaz Ali Memon, and Khalid Hussain Thebo

National Centre of Excellence in Analytical Chemistry, University of Sindh Jamshoro, Jamshoro, Pakistan

E-mail: ak.khalid@psau.edu.sa

Received: 6 July 2023  Accepted: 5 January 2024

Abstract:

Due to increase in infectious diseases, researchers are trying to synthesize effective, less toxic and inexpensive antimicrobial agents. For this, silver nanoparticles have been proved as potential antimicrobial agents. Therefore, in the present study, a supramolecular compound (calix[4]arene)-based silver nanoparticles (Calix–AgNPs (4)) were synthesized and applied as an efferent antimicrobial agent. The characterization of Calix–AgNPs was performed by UV–Vis, FTIR, SEM, XRD and Zetasizer techniques. Relative antimicrobial activity for synthesized calix[4]arene derivative (3) and Calix-AgNPs was explored against two types of bacteria (G + ve S. areus, and G – ve E.coli) and a fungal strain (R. stolonifer) using solution of silver nitrate salt as a reference. For antimicrobial study, five different dilutions of each compound derivative and Calix-AgNPs were prepared in acetonitrile (ACN) and deionized (DI) water, respectively. From results, it was revealed that Calix-AgNPs are efficient antimicrobial agents as compared to calix[4]arene derivative and silver salt. The minimum inhibitory value (MIC) was observed at 0.62 μg/mL against selected microorganisms for Calix-AgNPs.

Graphical abstract

Keywords: Calixarene; Antimicrobial activity; Minimum inhibitory concentration; Nanoparticles

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03420-7

Chemical Papers 78 (7) 4593–4603 (2024)