ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Recent developments on the synthesis of copper and cobalt-Schiff base complexes and their assessment as anti-tuberculosis drugs

Radhika Malav and Sriparna Ray

Department of Chemistry, School of Basic Sciences, Faculty of Science, Manipal University Jaipur, Dehmi Kalan, Jaipur, India

E-mail: sriparna.ray@gmail.com

Received: 22 November 2023  Accepted: 15 March 2024

Abstract:

The World Health Organization has identified tuberculosis (TB) as one of the major global health hazards and designated it as a “global public health emergency.” Although a decade of nonstop clinical research is past, globally, tuberculosis continues to be an extremely critical public health issue and the most prevalent infectious disease leading to death. It seems clear that finding new, promising medications to counter drug-resistant TB and managing the conditions are of highest priority. The simple Schiff bases are considered one of the oldest class of ancillary ligands, that are synthesized by condensation reaction between a carbonyl functional group (either an aldehyde or a ketone) and a primary amine. These ligands have been routinely utilized in the formation of stable complexes with transition metal ions. Due to the presence of imine or azomethine group in Schiff bases, these ligands and their transition metal complexes have been found to be the promising molecule for development of potent antimycobacterial drugs. Hence, this review recounts the recent reports on potential antitubercular properties of different Schiff base ligands and their corresponding copper and cobalt complexes in order to find novel and effective therapeutic agents to treat tuberculosis.

Keywords: Tuberculosis; Schiff base ligand; Bioactive heterocyclic moieties; Copper complexes; Cobalt complexes; Antitubercular activity

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-024-03425-2

Chemical Papers 78 (8) 4623–4646 (2024)