Abstract: A set of four C-8-aminomethyl derivatives of quercetin has been synthesized by Mannich reaction. The synthesis was carried out using a simple procedure to give target compounds as hydrochlorides. Study of oxidative hemolysis on mice erythrocytes showed that derivatives with morpholinomethyl or thiomorpholinomethyl groups favorably differ from the original quercetin by the ability to protect cells from acute oxidative stress.