ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Preparation and properties of dialkylaminoethoxyazachalcones

A. Brádlerová, J. Ďurinda, and E. Mišíková

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Komenský University, CS-832 32 Bratislava

Abstract:  Twenty 2-, 3-, and 4-(2-dialkylaminoethoxy)azachalcones have been syn­thesized by alkylation of hydroxyazachalcone, prepared in advance, or by Claisen—Schmidt condensation of dialkylaminoethoxybenzaldehydes with methyl pyridyl ketone. Ultraviolet, infrared, and ¹H-n.m.r. spectra were used to verify the identity of the prepared compounds and establish the geometrical isomerism and conformations. Preliminary tests for antimicrobial activity and acute toxicity have been carried out with some of the azachalcones prepared.

Full paper in Portable Document Format: 372a251.pdf

Chemical Papers 37 (2) 251–262 (1983)