ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Advanced pyrimidinone chemistry: a comprehensive review of synthetic pathways and biological potency

Ahmed A. Noser, Mohamed M. Khalifa, Ibtehal Nasser Salman, and Maha M. Salem

Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt

E-mail: ahmed.nosir@science.tanta.edu.eg

Received: 4 February 2026  Accepted: 10 April 2026

Abstract:

Heterocyclic compounds hold significant importance in medical chemistry. Pyrimidinone is a prominent heterocycle in this domain, demonstrating diverse medical applications including anticancer, antibacterial, antidiabetic, and anti-inflammatory properties. This review highlights current advancements in the synthesis of pyrimidinone derivatives by both traditional and environmentally friendly methods, and illustrates several chemical reactions associated with pyrimidinones. Additionally, the discussion encompasses the broad-spectrum therapeutic potential and industrial significance of pyrimidinone scaffolds. Ultimately, this research highlights that the advancement of pyrimidinone synthesis from 2022 to 2025 signifies not merely a technical transition but a strategic move towards high-efficiency, sustainable drug development that connects laboratory innovation with clinical applicability.

Graphical abstract

Keywords: Pyrimidinone; Biological applications; Dyes; Traditional methods; Green methods

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-026-04904-4

Chemical Papers 80 (9) 9953–9975 (2026)