ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Biocompatibility and antibacterial evaluation of zinc oxide nanoparticles synthesized via Arbutus unedo extracts

Muhammedul Emin Coban, Ozlem Tavukcuoglu, Duygu Misirli, Fatih Ciftci, and Mahfuz Elmastas

Faculty of Hamidiye Pharmacy, Department of Biochemistry, University of Health Sciences, Istanbul, Turkey

E-mail: ozlemoztolan@gmail.com

Received: 29 November 2024  Accepted: 17 April 2025

Abstract:

This study presents the green synthesis of zinc oxide nanoparticles (ZnONPs) using Arbutus unedo leaf (AUL) and fruit (AUF) extracts, emphasizing their biocompatibility and antibacterial potential. The synthesized nanoparticles were characterized by ultraviolet–visible spectroscopy (UV–Vis), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), Xray diffraction analysis (XRD), and transmission electron microscopy (TEM). Results confirmed the successful synthesis of AULZnONPs and AUFZnONPs, with average particle sizes of 12.30 ± 2.47 nm and 17.90 ± 3.70 nm, respectively. AULZnONPs and AUFZnONPs exhibited significant antibacterial activity against Escherichia coli (E. coli), with inhibition zone diameters of 13.18 ± 0.51 mm and 11.86 ± 0.33 mm, respectively. In vitro cytotoxicity evaluations demonstrated that both AULZnONPs and AUFZnONPs maintained high cell viability, significantly outperforming pristine ZnONPs.

Keywords: Bionanoelectronics; Nanomaterial; Nanoparticle Synthesis; Natural Products; Nanobiotechnology; Nanoparticles; Arbutus unedo; Green synthesis; Zinc oxide nanoparticles (ZnONPs); Antibacterial activity; Cytotoxicity; Biocompatibility; Nanomedicine

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-025-04073-w

Chemical Papers 79 (7) 4507–4519 (2025)