Albumin-based pH and salt-induced dispersive micro-solid-phase extraction of pesticide residues in grape juice combined with deep eutectic solvent-based dispersive liquid–liquid microextractionAysa Abbasalizadeh, Mahboob Nemati, Ramona Taati, Mir Ali Farajzadeh, Mohammad Reza Afshar Mogaddam, and Ali Pourali Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
E-mail: mr.afsharmogaddam@yahoo.com Received: 28 October 2024 Accepted: 18 May 2025 Abstract: This work reports the application of albumin as a cost-effective and competent adsorbent in dispersive solid-phase microextraction procedure for the extraction and preconcentration of four frequently applied pesticides (triticonazole, tebuconazole, difenoconazole, and penconazole) in grape juice samples. The extracted and enriched analytes quantification was done by gas chromatography–mass spectrometry. After extraction of the analytes, they were more concentrated by a dispersive liquid–liquid microextraction using deep eutectic solvents. The experimental variables impressed the offered method such as the amount of sorbent, and ionic strength, elution solvent nature, and volume were optimized. The proposed method offered precise determination of the selected pesticides in grape juice samples with proper repeatability (relative standard deviation ≤ 5.6%) and low limits of detection and quantification (0.03–0.11 and 0.09–0.36 ng mL−1, respectively). Ultimately, the developed method was successfully employed to determine the pesticide residues in grape juice samples. Keywords: Chromatography; Liquid-liquid extraction; Mass Spectrometry; Separation Science; Liquid chromatography; Solid-phase microextraction; Dispersive micro-solid-phase extraction; Pesticide; Dispersive liquid–liquid microextraction; Grape juice; Gas chromatogra Full paper is available at www.springerlink.com. DOI: 10.1007/s11696-025-04147-9
Chemical Papers 79 (8) 5575–5584 (2025) |
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