ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Amalgamation of Piper longum and honey into chitosan as wound dressing material

Sohail Shahzad, Sibtain Ahmed, Asma Yaqoob, Sadaf Saleem, Sumera Shaheen, Khayala Mammadova, Ahmad Kaleem Qureshi, Muhammad Arshad, Aamer Saeed, Dalal Hussien M. Alkhalifah, Faiz Ahmed, Wael N. Hozzein, Sana Javid, and Mohamed Mohany

Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan

E-mail: drsohail@uosahiwal.edu.pk

Received: 21 August 2024  Accepted: 6 May 2025

Abstract:

The increasing demand for biocompatible and effective wound-healing solutions has driven research into natural, antimicrobial-based dressings. Thus, growing concern about antibiotic resistance has led to exploring alternative infection treatments. By adding honey (HY) and Piper longum aqueous extract (PLAE) to chitosan (CHI)-based films, this study seeks to improve wound healing. The solvent casting method was used to create these films, which were then thoroughly examined utilizing SEM, FTIR, XRD, water transmission investigations, and dynamic mechanical examination. Additionally, histological examinations and rabbit wound-healing studies were used to evaluate their biodegradation, antibacterial activity, hemolytic qualities, and in vivo efficacy. The findings showed strong potential for wound healing, indicating that these films might be used as cutting-edge material for wound dressings. These films have a lot of potential for commercialization as bioactive wound dressings because of their natural composition and antibacterial effectiveness. Their use in the medical and pharmaceutical sectors may provide a viable and efficient substitute for traditional wound treatment methods.

Keywords: Honey; Piper longum aqueous extract; Antibacterial; Wound dressings

Full paper is available at www.springerlink.com.

DOI: 10.1007/s11696-025-04405-w

Chemical Papers 80 (1) 485–500 (2026)