ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Palladium-catalyzed heck and suzuki coupling in glycerol

A. Wolfson and C. Dlugy

Green Processes Center, Chemical Engineering Department, Sami Shamoon College of Engineering, Bialik/Basel Sts., Beer-Sheva, 84100, Israel

E-mail: adiw@sce.ac.il

Received: 20 October 2006  Revised: 5 December 2006  Accepted: 14 December 2006

Abstract: The Heck coupling of halobenzenes with various alkenes and the Suzuki cross coupling of halobenzenes with phenylboronic acid were successfully performed in glycerol as the reaction solvent using homogeneous and heterogeneous palladium catalysts. Glycerol is a renewable and recyclable green solvent that is able to dissolve organic substrates, inorganic bases, and palladium complexes, and that allows easy isolation of the reaction product by simple extraction with glycerol-immiscible solvents such as diethyl ether, hexane, and dichloromethane.

Keywords: Pd cross coupling - Heck reaction - Suzuki reaction - green solvent - liquid—liquid extraction

Full paper is available at www.springerlink.com.

DOI: 10.2478/s11696-007-0026-3

Chemical Papers 61 (3) 228–232 (2007)