ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

Synthesis and Cyclization Reactions with Quinolinyl Keto Esters. II. Synthesis of Novel 3-Diazolylquinolinones and their Enzymic Activity

M. M. Ismail and H. M. Mohamed

Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy 11711 Cairo, Egypt

E-mail: mmismail@chemist.com

Received: 11 September 2003

Abstract: Ethyl 4-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-2,4-dioxobutyrate, ethyl 5-(1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)pyrazole-3-caboxylate and their acid hydrozide derivatives have been prepared and reacted with hydrazines, o-phenylenediamine, triethyl orthoformate, carbon disulfide, and thiosemicarbazides in order to obtain some new 3-substituted quinolin-2-ones as: pyrazolines, isoxazolines, imidazoles, pyrazolotriazines, thiadiazoles, and triangles. All the newly prepared compounds revealed the potent effect on increasing reactivity of cellobimse. The structure of the new compounds was established upon their elemental analyses, IR, ¹H NMR, and mass fragmentation spectra.

Full paper in Portable Document Format: 592a127.pdf

Chemical Papers 59 (2) 127–138 (2005)