ISSN print edition: 0366-6352 ISSN electronic edition: 1336-9075 Registr. No.: MK SR 9/7 Published monthly

New compounds with cytotoxic and antitumor effects .8. Preparation and invitro activity of some pregnane derivatives on leukemia P-388 cells

A. Vassová Z. Votický, J. Fuska, and A. Fusková

Institute of Chemistry, Centre for Chemical Research, Slovak Academy of Sciences, CS-84238 Bratislava

Abstract: Eight new and six already known derivatives of pregnane were syn­thesized and their cytostastic in vitro activities on leukemia P 388 cells were tested. The most effective substance of this series was found to be (20R)--amino-3ß-acetoxy-5α -pregnane (Va), which preferentially inhibited in a 50—100 ug cm^-3 concentration the incorporation of [^l4C]-labelled uridine and L-valine in all P 388 fractions and stopped proliferation of cells in vitro.

Full paper in Portable Document Format: 412a271.pdf

Chemical Papers 41 (2) 271–277 (1987)